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Suboxone is a popularly approved medication to treat opiate withdrawal. It is one of two forms of the medication buprenorphine, which is an opiate agonist originally developed to treat pain problems. Suboxone works by binding to opiate receptors in the brain, which are the same receptors that morphine, heroin and other opiates bind to.

If you are not familiar with Suboxone, you might be more familiar with Methadone. Methadone was an earlier form of harm reduction treatments used to treat heroin addiction. Although Suboxone has treated thousands of patients struggling with opioid addiction, the drug is not without its risks. Critics continue to express concern over the lasting impact of Suboxone use when it comes to increasing dependency.

One huge concern of Suboxone use is the potential side effects of mixing other drugs with the substance. Suboxone can have dangerous interactions with other substances which pose an immediate risk to Suboxone users.

How Suboxone Works

In order to better understand the risk of combining drugs with Suboxone, it is important to understand how the drug works.  Suboxone is a combination of the drugs buprenorphine and naloxone. It functions as a partial opioid agonist and diminishes cravings as well as prevents other opioids from reacting to the brain’s receptors. In other words, even if you try to get high off opioids, you won’t.

Taking other drugs while on Suboxone can be life threatening. If you are on Suboxone, pay very close attention to the following three substances. Combining these drugs with Suboxone can cause a very dangerous, even fatal interaction.

3 Drugs You Should Never Mix With Suboxone:

1.) Benzodiazepines (“Benzos”)

Benzodiazepines (Xanax, Valium, Klonopin) are drugs usually prescribed to alleviate anxiety and treat insomnia. They are depressant drugs, or “downers,” because they sedate the central nervous system, which slows the heart rate, lowers blood pressure and depresses breathing. Because Suboxone is also a depressant drug, the two together create a double-whammy effect. The combination can cause a severe lack of coordination, impaired judgment, unconsciousness, respiratory failure, and even death.

2.) Cocaine

The effects of Suboxone and cocaine are extremely dangerous because both drugs are on opposite sides of the spectrum. Cocaine is a stimulant, or “upper,” while Suboxone is a depression, or “downer.” When you combine cocaine with Suboxone, it actually reduces the amount of buprenorphine that is in your bloodstream. When you have less buprenorphine in your body, you start to feel opioid withdrawal symptoms.
Combining cocaine with Suboxone increases the risk of a cocaine overdose. Since Suboxone is a depressant, it counteracts the effects of cocaine. This means users end up taking  more and more cocaine because they do not feel the effects they normally would on their regular amount. Typically, users start to believe that can handle more cocaine, even when they cannot. The increase in cocaine used can result in an overdose.

3.) Alcohol


Mixing alcohol with any medication is never a good idea, especially Suboxone. Just like benzos, alcohol is a depressant. Alcohol is even more of a problem than benzos because it is so readily available. An uninformed Suboxone user may not even consider the risks of drinking alcohol. However, combining alcohol and Suboxone can produce the same exacerbated effects such as unconsciousness and respiratory failure. These side effects can be dangerous and even fatal.It is so important to know all the risks you are taking with newly prescribed medication. According to statistics, there were 30,135 buprenorphine-related emergency room visits in 2010. It should come as no surprise that 59 percent of these visits involved additional drugs.

As Suboxone’s popularity increases, it is important to understand the dangers of mixing Suboxone with other substances. If you are taking Suboxone or similar drugs, it might be a good idea for you to consider seeking help on going off those drugs completely. Seeking professional treatment can help you not rely on any drugs in your recovery.  If you or someone you love is struggling with substance abuse or addiction, please call toll-free 1-800-951-6135.

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