Spokane is the largest city located in Spokane County. Spokane is located in the state of Washington. The city is located on the Spokane River. The city of Spokane (Spokane Falls) was settled in 1871 and officially incorporated as a city in 1881. Spokane has a population of about 209,000 and is considered to be the second largest city in Washington State. Daily life in Spokane is dictated by the weather and is lived very close to dozens of lakes. It is very common to go boating, rafting, skiing, hiking, biking and more. From anywhere in Spokane you could do something in the outdoors.